Valine Amino Acid Benefits

amino acids valine

Valine is an essential amino acid with an aliphatic side chain. It is non-polar in nature. It has GUC, GUU, GUA, and GUG codons. It was isolated from the casein in 1901 by German chemist Emil Fischer. It is hydrophobic amino acid found in the proteins. Its shape and volume roughly resemble the threonine amino acid and the only difference is the replacement of hydroxyl group with a methyl group in the valine. It also has branched chain.

Sources

Valine must be provided from the food. Some of its sources are as follow.

Animal origin: Valine sources from animal origin include meat, poultry, fish, dairy foods like cheese etc

Plant origin: Valine plant sources include lentils, peanuts, soy, mushrooms and sesame seeds.

Biosynthesis

 It is normally obtained from the hydrolysis of proteins. Valine is also manufactured in the plants from the pyruvate. Several enzymes take part in this process. These include acetohydroxy acid isomeroreductase, acetolactate synthase, valine aminotransferase and dihyroxyacid dehydratase.

The racemic valine is manufactured by bromination of isovaleric acid and then amination of bromo derivatives.

Functions

  • This branched-chain amino acid undergoes transamination reaction and results in the formation of alpha-keto acid and this reaction is catalyzed by branched chain transaminase. The alpha-keto acid then gives rise to acyl CoA derivatives with the help of enzymes. Acyl-CoA derivatives then form succinyl CoA which enters into the citric acid cycle.
  • Valine has some stimulating effects. It plays role in the muscle metabolism and also helps in growth and repair of tissues. Valine also maintains nitrogen balance in our body. Valine is the glucogenic amino acid so it provides glucose.
  • A disease known as maple serum urine disease results in case of error in metabolism of valine and it is then excreted in the urine.

If someone has taken a large amount of valine, then its toxicity occurs and is characterized by crawling sensations on the skin and feelings of hallucinations. So it should be taken with care in patients suffering from any liver or kidney diseases.

Related posts:

Isoleucine Amino Acid Benefits
Isoleucine is an essential amino acid so it needs to be provided by the food to our body. It has aliphatic side chain and is non-polar. It is also h...
Leucine Amino Acid Benefits
Leucine is the branched-chain amino acid with a non-polar aliphatic side chain. It is an essential amino acid as it cannot be synthesized by the body...
Methionine Amino Acid Benefits
Methionine is the uncharged polar amino acid. It is an essential amino acid as it is not synthesized in our body and must be provided through food. I...
Phenylalanine Amino Acid Benefits
Phenylalanine is the amino acid with the aromatic side chain and is relatively polar.  It is one of the essential amino acids which means i...
Arginine Amino Acid Benefits
Arginine is an amino acid with basic side chain and positive charge. It is one of the non-essential amino acids, therefore, it is produced in our bod...
Boost your "Feel Good" neurons...
What would you say if I would tell you that your happiness is right there in your brain...but you can't feel it because of all the other bad feelings ...