Isoleucine Amino Acid Benefits

amino acids isoleucine

Isoleucine is an essential amino acid so it needs to be provided by the food to our body. It has aliphatic side chain and is non-polar. It is also hydrophobic. It has AUU, AUA and AUC codons. Isoleucine along with threonine has a chiral side chain. There are four stereoisomers of isoleucine along with two diastereomers. It is glucogenic as well as ketogenic amino acid.

Sources

It is found in the following sources;

Animal Sources: Some of the isoleucine animal sources are meats, chicken, fish, turkey, lamb, egg, dairy products, cheese etc

Plant Sources: Some of the plant sources are soy protein, nuts, whole lentils, seaweeds, peanuts etc.

Synthesis

Isoleucine is not synthesized in our body. It must be ingested from foods. In a plant, it is synthesized from the pyruvate and alpha-ketoglutarate with the help of enzymes namely, dihydroxy-acid dehydratase, acetolactate synthase, valine aminotransferase and acetohydroxy acid isomeroreductase.

Physiological Functions

  • Isoleucine undergoes transamination and forms alpha-keto acid which is then converted into aceyl-CoA derivatives and which then gives rise to propionyl-CoA and acetyl-CoA. The propionly-CoA is converted to L-methylmalonyl-CoA and which then forms succinyl-CoA. These play role in the citric acid cycle then.
  • Isoleucine has the ability to increase strength and also heel and repair muscle tissues. 
  • It also promotes healing by clotting at the site of injury.
  • It also prevents muscle proteins break down when exercising. 
  • Isoleucine produces many compounds in our body which provides energy to us.
  • Isoleucine is also needed in children for their growth.
  • It also stabilizes and regulates blood sugar levels. This occurs as isoleucine is converted into glucose in the liver which then enters into the blood.

Isoleucine deficiency produces symptoms that are just like hypoglycemic symptoms for example in its deficiency a person may experience confusion, irritability, fatigue, depression, dizziness, headaches etc.

Isoleucine genetically altered metabolism leads to a disease called maple syrup urine disease. So these patients should avoid isoleucine supplements.

Isoleucine is also available in supplements and these supplements are helpful in the prevention of muscle wasting and promotion of tissue repair after surgery or trauma. These also increase muscle mass.

Related posts:

Histidine Amino Acid Benefits
Histidine is the glucogenic amino acid with a basic side chain. It is a weak base. After being incorporated in a protein molecule, histidine may show...
Methionine Amino Acid Benefits
Methionine is the uncharged polar amino acid. It is an essential amino acid as it is not synthesized in our body and must be provided through food. I...
Phenylalanine Amino Acid Benefits
Phenylalanine is the amino acid with the aromatic side chain and is relatively polar.  It is one of the essential amino acids which means i...
Threonine Amino Acid Benefits
Threonine is the uncharged polar amino acid. It is an essential amino acid as it is not manufactured in our body. It must be provided through food to...
Tyrosine Amino Acid Benefits
Tyrosine is the amino acid with an aromatic side chain. It has hydroxyl group for H bonds and shows polarity. It is a non-essential amino acid which ...
Glutamic Amino Acid Benefits
Glutamic acid is an amino acid with acidic side chain and a negative charge at neutral pH. It is nonessential amino acid as it is synthesized in the ...