Valine Amino Acid Benefits

amino acids valine

Valine is an essential amino acid with aliphatic side chain. It is non polar in nature. It has GUC, GUU, GUA, and GUG codons. It was isolated from the casein in 1901 by German chemist Emil Fischer. It is hydrophobic amino acid found in the proteins. Its shape and volume roughly resemble to the threonine amino acid and the only difference is the replacement of hydroxyl group with a methyl group in the valine. It also has branched chain.

Sources

Valine must be provided from the food. Some of its sources are as follow.

Animal origin: Valine sources from animal origin includes meat, poultry, fish, dairy foods like cheese etc

Plant origin: Valine plant sources include lentils, peanuts, soy, mushrooms and sesame seeds.

Biosynthesis

 It is normally obtained from the hydrolysis of proteins. Valine is also manufactured in the plants from the pyruvate. Several enzymes take part in this process. These include acetohydroxy acid isomeroreductase, acetolactate synthase, valine aminotransferase and dihyroxyacid dehydratase.

The racemic valine is manufactured by bromination of isovaleric acid and then amination of bromo derivatives.

Functions

  • This branched chain amino acid undergoes transamination reaction and results in formation of alpha keto acid and this reaction is catalyzed by branched chain transaminase. The alpha keto acid then gives rise to acyl CoA derivatives by the help of enzymes. Acyl-CoA derivatives then form succinly CoA which enters into the citric acid cycle.
  • Valine has some stimulating effects. It plays role in the muscle metabolism and also helps in growth and repair of tissues. Valine also maintains nitrogen balance in our body. Valine is the glucogenic amino acid so it provides glucose.
  • A disease known as maple serum urine disease results in case of error in metabolism of valine and it is then excreted in the urine.

If someone has taken large amount of valine, then its toxicity occurs and is characterized by crawling sensations on the skin and feelings of hallucinations. So it should be taken with care in patients suffering from any liver or kidney diseases.

Related posts:

Amino Acids Found in Human DNA
There are twenty amino acids (AA) which have been found to occur in all proteins and for which genetic codon exits. Each of these has one or more g...
Histidine Amino Acid Benefits
Histidine is the glucogenic amino acid with basic side chain. It is a weak base. After being incorporated in a protein molecule, histidine may show ...
Leucine Amino Acid Benefits
Leucine is the branched chain amino acid with non-polar aliphatic side chain. It is an essential amino acid as it cannot be synthesized by the body....
Selenocysteine Amino Acid Benefits
Selenocysteine amino acid is the analog of cysteine having the same structure as that of cysteine. But here sulphur atom is replaced by selenium. It...
Asparagine Amino Acid Benefits
Asparagine amino acid is a non essential amino acid as it is being produced in our body from the other amino acid. It is one of the natural amino ac...
Cysteine Amino Acid Benefits
Cysteine is an uncharged amino acid with polar side chain and hydrophobic in nature. It is sulphur containing amino acid and S atom in cysteine is i...