Pyrrolysine Amino Acid Benefits

amino acids pyrrolysine

Pyrrolysine is the largest amino acid known which is naturally occurring. It is encoded genetically by a nucleotide sequence that usually halts the translation of mRNA.

It is found in bacterium and in few species of Archaea. It is just like the lysine but it is different in having pyrrole ring which is attached to the one end of the lysine amino acid.


In our body pyrrolysine is produced by special transfer RNA and an enzyme called aminoacyl transfer RNA. This amino acid also forms a part of genetic code.


In our body it is incorporated into active sites of many enzymes for example methyltransferase. Here on this enzyme is rotated freely. It is incorporated during the process of translation in to messenger RNA with the help of codon UAG. This amino acid has not been studies too much. There are not many known functions of it.


It contains three chiral centers which results in eight enantiomers, but only one of these is utilized. Pyrrolysine is a labile amino acid and it can easily be destroyed by heat and acid hydrolysis. This amino acid was also found to be involved in the methanogenesis. The methane today is the green house gas which is quite powerful. Pyrrolysine is the twenty second amino acid of proteinogenic type.

Related posts:

Histidine Amino Acid Benefits
Histidine is the glucogenic amino acid with basic side chain. It is a weak base. After being incorporated in a protein molecule, histidine may show ...
Lysine Amino Acid Benefits
Lysine is the amino acid with the basic side chain. It is an essential amino acid as it is not manufactured in our body so it needs to be supplied f...
Selenocysteine Amino Acid Benefits
Selenocysteine amino acid is the analog of cysteine having the same structure as that of cysteine. But here sulphur atom is replaced by selenium. It...
Threonine Amino Acid Benefits
Threonine is the uncharged polar amino acid. It is an essential amino acid as it is not manufactured in our body. It must be provided through food t...
Tryptophan Amino Acid Benefits
Tryptophan amino acid is the essential amino acid. This means it must be provided through food to the body. It is one of the amino acid which in its...
Arginine Amino Acid Benefits
Arginine is an amino acid with basic side chain and positive charge. It is one of the non essential amino acid therefore it is produced in our body ...