Amino acids for brain: DL-Phenylalanine and L-Glutamine


There are 300 naturally occurring amino acids (AA) but only twenty take parts in the formation of proteins, plant as well as animal in origin. They are working substance in all cells. They make the protein more complex. They are linked by peptide bonds. They are also classified according to our body need into essential and non essential amino acid.

Essential ones are those which body cannot make and they must be provided by the food. These are histidine, leuocine, isoleucine, lysine, methionine, phenlyalanine, threonine, tryptophan and valine.

Non Essential are those which body can make, these are alanine, arginine, asparagines, aspartic acid, cysteine, glutaminc acid, glutamine, glycine, proline, serine and tyrosine.

Although all of them share a common structure, they differ in size, shape, electrical charge and other characteristics because of differenced in their side chains. The amino acid sequence can be explained as follow; if a person is to walk along a polypeptide chain, each stepping stone will be one of the 20 odd different AA. The first step stone may be the methionine. The second may be an alanine. The third may be a glycine and a fourth a tryptophan and do on. Walking along another polypeptide path, a person may step on proline, then valine. It also describe that their sequence within the protein vary.

Even though they are needed to do the work that only they can perform i.e. build vital proteins but they can be sacrificed to give energy and glucose if need. They can be used to make fats e.g. if the person eat too much protein than his body needs, AA are deaminated, the nitrogen is excreted and the remaining carbohydrate fragments are converted to fats and stored for later use.

They are even helpful in evaluating the food’s protein quality. They can further be used to make other essential compounds. Like wise they have wide range of effects, particularly important effects on brain are as given.

Effects of DL-Phenylalanine and L-Glutamine Amino Acids over the Brain.

DL-phenylalanine: is a nutritional supplement and acts as analgesic and anti-depressant. It is actually the mixture of D-phenylalanine and L- phenylalanine.

It provides analgesic effect by acting on the brain. It does so by blocking the degradation of DL-phenylalanine of endorphin by the help of enzyme carboxypeptidase.

As we know L-phenylalanine is precursor in the synthesis of epinephrine and norepinephrine and decrease levels of them result in depression in an individual. So its antidepressant effect is because it blocks endorphin degradation, this thing leads to inhibition of GABA in the midbrain and the result is increase dopamine release.

L-Glutamine: It is also a nutritional supplement and it can easily enter the brain where it is used for energy and is a precursor to nerve transmitters both excitatory and inhibitory. If brain does not get glucose, glutamine can be metabolized for energy by the brain as compensation. L-Glutamine also plays an important role during stress and in optimum protein metabolism and utilization both in the brain as well as in the gastrointestinal system. People who use them often report as being happy and energetic and less fatigue.

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